Below are links to some of the published papers and guidelines on SCAD


European Society of Cardiology (ESC) 2020 Acute Coronary Syndromes (ACS) Clinical Practice Guidelines

Published 1 September. SCAD has a section for the first time, see pages 37-38 section 6.1.5.

Spontaneous Coronary Artery Dissection, JACC State-of-the-Art Review

Journal of the American College of Cardiology, Sharonne N. Hayes, Marysia S. Tweet, David Adlam, Esther S.H. Kim, Rajiv Gulati, Joel E. Price and Carl H. Rose, Published August 2020

Audio summary by Editor-in-Chief Dr. Valentin Fuster on

Psychological and clinical characteristics of patients with spontaneous coronary artery dissection: A case-control study.

International Journal of Cardiology, Veerle R.Smaardijkac, Paula M.C. Mommersteega, Willem J.K opa, Dario Pellegrinibc, Robert-Janvan Geunsc, H.E.M. Angelac, 14 August 2020

Spontaneous coronary artery dissection, a commonly overlooked etiology of acute coronary syndrome

Journal of Community Hospital Internal Medicine Perspectives, Ashish Kumar Roy, Moni Roy, Manajyoti Yadav,K alyan C. Potu, Sudhir Mungee, Published 2 Aug 2020

Recurrent spontaneous coronary artery dissection in a middle-aged male athlete patient: a case report

European Heart Journal – Case Reports, John J Fitzpatrick, Awsan Noman, Nicola Ryan, Dana K Dawson, Published 30 July 2020

Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia: Vasculopathies With a Predilection for Women

Heart Lung and Circulation, Siiri E. Iismaa, PhD, Stephanie Hesselson, PhD, Lucy McGrath-Cadell, MD, Eleni Giannoulatou, DPhil, Jason Kovacic, MD, PhD, Robert M. Graham, MD, Published 6 July 2020

Psychological and clinical characteristics of female patients with spontaneous coronary artery dissection

Netherlands Heart Journal, V. R. Smaardijk · P. M. C. Mommersteeg · W. J. Kop · D. Adlam · A. H. E. M. Maas, Published June 2020

Analysis of Posttraumatic Stress Disorder, Depression, Anxiety, and Resiliency Within the Unique Population of Spontaneous Coronary Artery Dissection Survivors

Journal of the American Heart Association, Alexis K. Johnson, Sharonne N. Hayes, Craig Sawchuk, Matthew P. Johnson, Patricia J. Best, Rajiv Gulati, and Marysia S. Tweet, Published 28 April 2020

Identification of Susceptibility Loci for Spontaneous Coronary Artery Dissection

JAMA Cardiology, Tamiel N. Turley, BS1; Megan M. O’Byrne, MA2; Matthew L. Kosel, BS2; et al Mariza de Andrade, PhD2; Rajiv Gulati, MD, PhD3; Sharonne N. Hayes, MD3; Marysia S. Tweet, MD3; Timothy M. Olson, MD3,4, Published 6 May 2020

Rare Loss-of-function Mutations of PTGIR are enriched in Fibromuscular Dysplasia

Cardiovascular Research, Adrien Georges, PhD, Juliette Albuisson, MD, PhD, Takiy Berrandou, PhD, Délia Dupré, Msc, Aurélien Lorthioir, MD, Valentina D’Escamard, MD, PhD, Antonio F Di Narzo, PhD, Daniella Kadian-Dodov, MD, Jeffrey W Olin, MD, Ewa Warchol-Celinska, MD, PhD et al, Published: 12 June 2020

Chronic infarct size after spontaneous coronary artery dissection: implications for pathophysiology and clinical management

European Heart Journal, Abtehale Al-Hussaini, Ahmed M S E K Abdelaty, Gaurav S Gulsin, Jayanth R Arnold, Marcos Garcia-Guimaraes, Diluka Premawardhana, Charley Budgeon, Alice Wood, Nalin Natarajan, Kenneth Mangion, Roby Rakhit, Stephen P Hoole, Thomas W Johnson, Colin Berry, Ian Hudson, Anthony H Gershlick, Andrew Ladwiniec, Jan Kovac, Iain Squire, Nilesh J Samani, Sven Plein, Gerry P McCann, David Adlam, Published 14 June 2020


Association of the PHACTR1/EDN1 genetic locus with spontaneous coronary artery dissection

Journal of the American College of Cardiology, Published 7 January 2019

PHACTR1 paper explained by the NIHR Leicester Biomedical Research Centre

PHACTR1 paper explained by Dr David Adlam

Spontaneous coronary artery dissections and associated predisposing factors: a narrative review

Netherlands Heart Journal, B. N. J. Janssen, P. W. de Leeuw & A. H. E. M. Maas, Published 25 January 2019

Rare Missense Variants in TLN1 Are Associated With Familial and Sporadic Spontaneous Coronary Artery Dissection

Circulation: Genomic and Precision Medicine, Tamiel N. Turley, Jeanne L. Theis, Rhianna S. Sundsbak, Jared M. Evans, Megan M. O’Byrne, Rajiv Gulati, Marysia S. Tweet, Sharonne N. Hayes, Timothy M. Olson, Published 19 March 2019

Spontaneous coronary artery dissection: no longer a rare disease

European Heart Journal, David Adlam, Marcos García-Guimaraes, Angela H E M Maas, Published 14 April 2019

Characterization and outcomes of spontaneous coronary artery dissection patients presenting with an acute coronary syndrome: insights from the ACALM registry

Heart, Rahul Potluri, Paul Carter, Amir Aziz, Minh Vo, Ranjit More, Jaydeep Sarma, Asif Ahmed, David Adlam, Robert Welsh, Kevin Bainey, Published May 2019

Spontaneous coronary artery dissection (SCAD)

Vascular Medicine, Ivka Stimach, Esther SH Kim, Khendi White Solaru, et al, Published 14 October 2019

Spontaneous Coronary Artery Dissection in Patients With a Provisional Diagnosis of Takotsubo Syndrome

Journal of the American Heart Association, Anaïs Hausvater, Nathaniel R. Smilowitz, Jacqueline Saw, Mark Sherrid, Thara Ali, Dalisa Espinosa, Rediet Mersha, Maria DeFonte, and Harmony R. Reynolds, Published 12 November 2019

Editorial on: ‘Characteristics of extension and de novo recurrent spontaneous coronary artery dissection’

David Adlam, DPhil, FRCP; Alice Wood, MBBS, MRCP; Abtehale Al-Hussaini, MBBS, MRCP

Spontaneous Coronary Artery Dissection: Pathophysiological Insights from Optical Coherence Tomography

JACC: Cardiovascular Imaging, Published December 2019

An Unusual Presentation of Postpartum Spontaneous Coronary Artery Dissection

University of California, Alterie, Jonathan D., Villanueva, Francis, Arekat, Mohamed, Brill, April, Published 2019


European Society of Cardiology, acute cardiovascular care association, SCAD study group: a position paper on spontaneous coronary artery dissection

David Adlam, Fernando Alfonso, Angela Maas, Christiaan Vrints, Writing Committee, Published 22 February 2018

Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association

Circulation, Sharonne N. Hayes, Esther S.H. Kim, Jacqueline Saw, David Adlam, Cynthia Arslanian-Engoren, Katherine E. Economy, Santhi K. Ganesh, Rajiv Gulati, Mark E. Lindsay, Jennifer H. Mieres et al and On behalf of the American Heart Association Council on Peripheral Vascular Disease; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Genomic and Precision Medicine; and Stroke Council, Published 22 February 2018

Spontaneous Dissections of Coronary Arteries (SCAD) and Acute Coronary Syndromes (ACS). Preliminary Results of the Discovery – ACS: A Multicenter Prospective Registry With A Patients-control Group

Alessandro Fontanelli, Alessandra Benettin, Carlo Bonanno, Ester Cabianca, Alessandro Desideri, Andrea Santarelli, Luigi La Vecchia, and Leopoldo Pagliani, Published 22 March 2018

Prospective Cardiovascular Genetics Evaluation in Spontaneous Coronary Artery Dissection

Circulation: Genomic and Precision Medicine, Ihsan Kaadan, Carolyn MacDonald, Francesca Ponzini, Jessica Duran, Kelsey Newell, Linda Pitler, Angela Lin, Ido Weinberg, Malissa J. Wood, and Mark E. Lindsay, Published 12 April 2018

Familial Spontaneous Coronary Artery Dissection – Evidence for Genetic Susceptibility

Circulation, Kashish Goel, Marysia Tweet, Timothy M Olson, Joseph J Maleszewski, Rajiv Gulati, and Sharonne Hayes, Published 27 Mar 2018

Early Natural History of Spontaneous Coronary Artery Dissection

Circulation: Cardiovascular Interventions, Thomas M. Waterbury, Marysia S. Tweet, Sharonne N. Hayes, Mackram F. Eleid, Malcolm R. Bell, Amir Lerman, Mandeep Singh, Patricia J.M. Best, Bradley R. Lewis et al, Published 14 September 2018

British Cardiovascular Society Openheart journal article summarising the European Position Paper and American Scientific Statement.

Published 5 November 2018

Whole Exome Sequencing of Spontaneous Coronary Artery Dissection (SCAD) Cases Discovers Enrichment of Rare Disruptive Variants in Fibrillar Collagen Genes

Circulation, Seyedeh M Zekavat, Erina Kii, Mark Chaffin, Krishna Aragam, Malissa J Wood, Hongyu Zhao, Sekar Kathiresan, Mark E Lindsay, and Pradeep Natarajan, Published 5 November 2018

Spontaneous coronary artery dissections and fibromuscular dysplasia: Current insights on pathophysiology, sex and gender

International Journal of Cardiology, Angela H.E.M. Maas, Nabila Bouatia-Naji, Alexandre Persu, David Adlam, Published 9 November 2018

Prevalence and Clinical Factors of Migraine in Patients With Spontaneous Coronary Artery Dissection

Journal of the American Heart Association, Susan N. Kok, Sharonne N. Hayes, F. Michael Cutrer, Claire E. Raphael, Rajiv Gulati, Patricia J. M. Best, and Marysia S. Tweet, Published 13 December 2018


Spontaneous coronary artery dissection

Heart, Abtehale Al-Hussaini, David Adlam, Published July 2017


The First Dedicated Cardiac Rehabilitation Program for Patients With Spontaneous Coronary Artery Dissection: Description and Initial Results

Science Direct, Annie Y.Chou MD, Roshan Prakash MD, Jennifer Rajala MD, Taira Birnie BSc, Saul Isserow MD, Carolyn M.Taylor MD, Andrew Ignaszewski MD, Sammy Chan MD, Andrew Starovoytov MD, Jacqueline Saw MD, Published April 2016

Spontaneous coronary artery dissection and its association with heritable connective tissue disorders

Heart, June 2016, Stanislav Henkin, Sara M Negrotto, Marysia S Tweet, Salman Kirmani, David R Deyle, Rajiv Gulati, Timothy M Olson, Sharonne N Hayes



What Clinicians should know about SCAD

Mayo Clinic, Marysia S. Tweet, MD; Rajiv Gulati, MD, PhD; and Sharonne N. Hayes, MD


Coronary Artery Tortuosity in Spontaneous Coronary Artery Dissection, Angiographic Characteristics and Clinical Implications

Circulation: Cardiovascular Interventions, Mackram F. Eleid, Raviteja R. Guddeti, Marysia S. Tweet, Amir Lerman, Mandeep Singh, Patricia J. Best, Terri J. Vrtiska, Megha Prasad, Charanjit S. Rihal, Sharonne N. Hayes, and Rajiv Gulati, Published 19 August 2014

Spontaneous Coronary Artery Dissection, Association With Predisposing Arteriopathies and Precipitating Stressors and Cardiovascular Outcomes

Circulation: Cardiovascular Interventions, Jacqueline Saw, Eve Aymong, Tara Sedlak, Christopher E. Buller, Andrew Starovoytov, Donald Ricci, Simon Robinson, Tycho Vuurmans, Min Gao, Karin Humphries, and G.B. John Mancini, Published 1 October 2014

Spontaneous Coronary Artery Dissection, Revascularization Versus Conservative Therapy

Circulation: Cardiovascular Interventions, Marysia S. Tweet, Mackram F. Eleid, Patricia J.M. Best, Ryan J. Lennon, Amir Lerman, Charanjit S. Rihal, David R. HolmesJr, Sharonne N. Hayes, and Rajiv Gulati, Published 18 November 2014